Quick answer: Epithalon (also written Epitalon or Epithalone) is a four-amino-acid peptide studied mainly in telomerase and pineal gland research. DSIP is a nine-amino-acid peptide studied mainly in sleep-related neuroendocrine research. They are different molecules with different sequences, sizes and proposed targets, and both are supplied by us for laboratory research use only.
How do Epithalon and DSIP compare at a glance?
Both are short peptides, and both appear in circadian and neuroendocrine literature. That overlap is why they get compared. The table shows where they separate.
| Feature | Epithalon | DSIP |
|---|---|---|
| Sequence | Ala-Glu-Asp-Gly (AEDG) | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu |
| Length | 4 amino acids | 9 amino acids |
| Approximate molecular weight | About 390 g/mol | About 849 g/mol |
| Proposed target | Telomerase-related pathways and pineal signaling; no single receptor is established | No single receptor is firmly established |
| Main research areas | Telomere biology, cellular aging, melatonin and circadian regulation | Sleep-related brain activity, stress and neuroendocrine signaling |
| Published half-life | No well-established value we can cite | Reported as short in early studies |
| Catalog size | 50mg vial | 5mg and 10mg vials |
What has Epithalon research examined?
Epithalon is described as a synthetic peptide proposed from epithalamin, an extract of the pineal gland. Researchers have examined it in two areas.
- Telomeres. Telomeres are the protective caps at the ends of chromosomes. Cell culture studies reported that Epithalon was associated with telomerase activity, the enzyme that maintains those caps.
- Pineal and circadian signaling. Preclinical research looked at melatonin output and the body clock.
These are reports from laboratory studies. They are not statements about what the product does for anyone.
What has DSIP research examined?
DSIP stands for delta sleep-inducing peptide. It was first described in the 1970s, and we cover that story in DSIP History: How Delta Sleep-Inducing Peptide Was Found. Preclinical studies looked at its link to sleep-related brain activity, stress responses and hormone signaling. Its mechanism is still debated, and no single receptor has been settled on.
Which peptide has stronger evidence?
Neither has deep evidence. Published Epithalon work is concentrated in a small number of related research groups, and independent replication is thinner than the number of papers suggests. DSIP has a longer paper trail, but its target is unclear and results across studies have varied. For both, treat the research as early and limited.
How do you tell them apart on a COA?
A Certificate of Analysis (COA) should make mix-ups easy to catch. For the general method, see How to Read a Peptide Certificate of Analysis. For these two peptides, look at:
- Mass. Mass spectrometry measures molecular weight. Epithalon should read near 390; DSIP near 849. A result far from the expected mass means the wrong or a damaged peptide.
- Sequence length. At four residues, Epithalon is small and polar, so it elutes early on HPLC (the purity method). Early peaks need careful reading.
- UV absorbance. DSIP contains tryptophan, which absorbs light at 280 nm. AEDG has no such residue, so it is typically monitored at lower wavelengths.
- Content per vial. Purity is not the same as how much peptide is in the vial. Check that the COA states content as well as percentage purity.
What is in the Epithalon 50mg vial?
The Epithalon (Epitalon) 50mg product is a lyophilized (freeze-dried) powder, research grade, with 50mg per vial. Our peptides are synthesized at a WHO/GMP and ISO 9001 certified laboratory in California. If you are also looking at the other compound, the DSIP 10mg vial is a separate product with its own COA.
Frequently asked questions
Is Epithalon the same as Epitalon?
Yes. Epithalon, Epitalon and Epithalone are spelling variants of the same four-amino-acid peptide, AEDG.
What does AEDG stand for?
It is the one-letter code for the sequence: A is alanine, E is glutamic acid, D is aspartic acid and G is glycine.
Is Epithalon a natural peptide?
Our Epithalon is made by chemical synthesis. Researchers proposed the sequence based on epithalamin, a pineal gland extract.
Do Epithalon and DSIP act on the same pathway?
Not as far as published research shows. Epithalon work centers on telomerase and pineal signaling, while DSIP work centers on sleep-related neuroendocrine signaling. Both targets remain incompletely defined.
Where is BioPure Epithalon made?
It is synthesized at a WHO/GMP and ISO 9001 certified laboratory in California, then supplied by BioPure Peptides for laboratory research use only.
Every lot we sell has a Certificate of Analysis you can read before you order. Questions before you buy? Our team is in Chandler, Arizona: (888) 745-1505 or our contact page.
View Epithalon (Epitalon) | 50mgAll products sold by BioPure Peptides are intended strictly for in-vitro laboratory and research use only. They are not for human or animal consumption. These statements have not been evaluated by the U.S. Food and Drug Administration, and these products are not intended to diagnose, treat, cure, or prevent any disease.