Kisspeptin-10 (KP-10), also known as Metastin (45–54), is the shortest biologically active fragment of the kisspeptin peptide family derived from the KISS1 gene. This decapeptide functions as a high-affinity agonist of the Kisspeptin receptor (KISS1R / GPR54) and is widely utilized as a research tool in neuroendocrine and reproductive signaling studies.

Kisspeptin-10 is extensively studied for its role in regulating upstream signaling mechanisms involved in gonadotropin-releasing hormone (GnRH) activity. Due to its minimal active sequence and well-characterized receptor interaction, KP-10 is frequently selected for controlled laboratory investigations requiring precise receptor activation.

Intended Use:
For Research Use Only (RUO). Not intended for diagnostic or therapeutic applications.

In experimental and preclinical research models, Kisspeptin-10 has been investigated for its involvement in a wide range of biological signaling pathways related to endocrine regulation, neurobiology, and cellular communication. Current scientific literature suggests associations with the following physiological processes:

• Androgen-Related Signaling Pathways
  Investigated for its role in upstream regulation of gonadal hormone signaling, including pathways associated with testosterone modulation in endocrine research models.
• Sex-Related Behavioral Signaling
  Studied in relation to neural circuits involved in reproductive behavior, motivational signaling, and drive-associated neuroendocrine pathways.
• Mood and Behavioral Regulation Pathways
  Explored for its interaction with hypothalamic and limbic signaling networks associated with emotional regulation and behavioral responses.
• Neurocognitive and Brain Function Research
  Evaluated for its role in central nervous system signaling, neuronal communication, and cognitive-related peptide pathways.
• Immune System Signaling Research
  Investigated for potential interactions between endocrine peptides and immune-modulatory signaling cascades in experimental systems.
• Cellular Aging and Tissue Integrity Pathways
  Studied in relation to cellular turnover, oxidative stress signaling, and mechanisms associated with structural protein regulation and tissue maintenance.
• Metabolic and Energy Balance Signaling
  Explored for involvement in appetite regulation pathways, energy expenditure signaling, and metabolic feedback loops.
• Fertility and Reproductive Axis Regulation
  Extensively researched for its role in coordinating signaling within the hypothalamic–pituitary–gonadal (HPG) axis and fertility-associated regulatory mechanisms.

Chemical & Technical Specifications

• Peptide Name: Kisspeptin-10
• Synonyms: KP-10; Metastin (45–54); KISS1 Decapeptide
• CAS Number: 374675-21-5
• Amino Acid Sequence:
  Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
• Molecular Formula: C₆₃H₈₃N₁₇O₁₄
• Molecular Weight: Approximately 1302.4 g/mol

Physical Characteristics

• Appearance: White to off-white lyophilized powder
• Purity: ≥ 99% (HPLC verified)
• Solubility: Soluble in sterile water or compatible laboratory buffers

Storage & Handling

• Store lyophilized peptide at –20 °C or below
• Reconstituted solutions should be stored at 2–8 °C and used promptly
• Handle using appropriate laboratory safety procedures and personal protective equipment

Quality Assurance

• Synthesized under controlled laboratory conditions
• Verified for identity and purity using analytical testing
• Supplied with a Certificate of Analysis (COA)
• Manufactured, labeled, and distributed in compliance with Research Use Only standards

Compliance Notice

This product is intended exclusively for in-vitro laboratory research.
It is not intended for use in diagnostic, therapeutic, or clinical applications.