Vasoactive Intestinal Peptide (VIP) is a synthetic form of a naturally occurring 28-amino-acid neuropeptide belonging to the secretin/glucagon peptide family. VIP is widely distributed throughout the body and is endogenously expressed in the central and peripheral nervous systems, as well as within gastrointestinal, respiratory, and immune-associated tissues.

VIP interacts primarily with the VPAC1 and VPAC2 G protein-coupled receptors, influencing intracellular signaling pathways such as cAMP activation. In laboratory research settings, VIP is commonly utilized as a peptide tool for studying receptor-mediated signaling, neuro-immune communication, smooth muscle physiology, and inflammatory pathway regulation.

This product is supplied strictly for in vitro and preclinical research applications and is not intended for human or animal use.

Chemical Information

• Peptide Name: Vasoactive Intestinal Peptide
• Abbreviation: VIP
• CAS Number: 37221-79-7
• Molecular Formula: C₁₄₇H₂₃₈N₄₄O₄₂S
• Molecular Weight: ~3326.8 g/mol
• Amino Acid Length: 28 residues

Research-Based Functional Insights

Based on published findings in scientific literature, VIP is frequently referenced in research involving the following biological and biochemical areas:

Neuropeptide Signaling & CNS Research

VIP is widely studied as a neuromodulator involved in neuronal signaling pathways. It is frequently included in experimental research examining neurotransmission, neuronal receptor signaling, and neuropeptide-regulated cellular communication.

cAMP Pathway Activation

VIP is commonly used in receptor pharmacology studies due to its ability to activate intracellular adenylate cyclase and cAMP signaling cascades through VPAC receptor binding. This makes VIP valuable in studies investigating second messenger pathways and downstream transcription responses.

Smooth Muscle & Vasodilation Research

VIP is frequently referenced in models involving smooth muscle relaxation and vascular tone regulation, including studies focused on vasodilatory mechanisms, vascular receptor mapping, and peptide-mediated modulation of circulatory function.

Pulmonary and Airway Research

VIP is used in respiratory research models due to its signaling effects in airway and pulmonary tissues. Experimental studies investigate its influence on airway smooth muscle behavior, pulmonary vascular regulation, and neurogenic signaling pathways in lung-related systems.

Gastrointestinal Motility and Secretory Studies

VIP plays a recognized role in gastrointestinal physiology and is frequently included in studies examining intestinal motility, epithelial secretion, and fluid/electrolyte transport mechanisms in controlled experimental settings.

Immune System Modulation

VIP is often referenced in immune research due to its reported ability to influence immune cell signaling. Studies explore its interactions with macrophages, dendritic cells, and T-cell responses, as well as its impact on immune regulatory pathways.

Cytokine and Inflammatory Pathway Research

VIP is commonly utilized in laboratory research focused on cytokine regulation and inflammatory mediator pathways. Research models investigate VIP’s potential influence on inflammatory signaling cascades, including mechanisms related to immune balance and cellular stress responses.

Neuro-Immune Communication

VIP is frequently studied for its role in cross-communication between nervous and immune systems. This includes investigations into how neuropeptides influence immune cell activation, tissue-level inflammatory responses, and systemic signaling networks.

Circadian Rhythm & Hypothalamic Signaling

VIP is a well-documented signaling peptide in circadian rhythm studies. It is commonly used in research investigating hypothalamic pathways, biological clock regulation, and neuronal signaling associated with circadian control mechanisms.

Cellular Protection and Stress Response Research

Some experimental studies include VIP in research models exploring cellular survival pathways and oxidative stress response mechanisms, including signaling effects on apoptosis-related pathways in controlled systems.

All referenced activities are based on in vitro or animal-based research models and are provided for scientific informational purposes only. These statements do not imply clinical outcomes or therapeutic applications.

Intended Use

This product is intended for use by qualified professionals in controlled laboratory and research environments only.

Regulatory & Compliance Statement

• For Research Use Only (RUO)
• Not for Human or Veterinary Use
• Not for Diagnostic or Therapeutic Purposes
• Not FDA Approved