Quick answer: Kisspeptin-10 (KP-10) is a ten-amino-acid peptide, the shortest fragment of the kisspeptin family that still activates the kisspeptin receptor. It is also called Metastin (45-54). Researchers use it as a tool to study reproductive and neuroendocrine signaling, and we supply it for laboratory research use only.
What is Kisspeptin-10?
If you are asking what is Kisspeptin-10, start with the name. Kisspeptins are peptides made from a gene called KISS1. A peptide is a short chain of amino acids, the building blocks of proteins. Kisspeptin-10 is a decapeptide, meaning it has ten of them.
Our product page describes it as the shortest biologically active fragment of the family. It acts as a high-affinity agonist of the kisspeptin receptor, written KISS1R or GPR54. An agonist is a molecule that switches a receptor on. Because the fragment is small and its target is well characterized, researchers often pick it when they want a clean, controlled receptor signal in the lab.
Why is it called Metastin (45-54)?
The first member of the family was named metastin. The numbers refer to positions in that longer chain. "45-54" means the last ten amino acids, positions 45 through 54. Kisspeptin-10 is that end segment cut out of the larger peptide.
| Feature | Kisspeptin-10 | Full-length metastin |
|---|---|---|
| Also written as | KP-10, Metastin (45-54) | Kisspeptin-54 |
| Length | 10 amino acids | 54 amino acids |
| Receptor | KISS1R / GPR54 | KISS1R / GPR54 |
| Why researchers choose it | Minimal active sequence | Complete native-length chain |
Both reach the same receptor. The short version is simply the smallest piece that still does the job.
What has Kisspeptin-10 been studied for?
The central research topic is the reproductive axis. Researchers examine how kisspeptin signaling sits upstream of gonadotropin-releasing hormone (GnRH), the signal that starts a cascade of reproductive hormones. That is the most developed area in the literature, and it is mostly laboratory and preclinical work.
Our product page lists other areas where the literature reports associations in experimental models:
- Androgen-related signaling pathways
- Neural circuits tied to reproductive and motivational behavior
- Mood and behavioral regulation networks
- Brain function and neuronal communication
- Immune signaling
- Cellular aging and tissue maintenance pathways
- Appetite, energy and metabolic feedback signaling
- Fertility and reproductive axis regulation
Treat that list with care. An "association" in a cell or preclinical model is not a proven effect, and the evidence outside the reproductive axis is much thinner and earlier. Nothing here describes what the peptide will do for you.
What is in the Kisspeptin-10 vial?
Each vial holds our Kisspeptin-10 as a research peptide. Our peptides are synthesized at a WHO/GMP and ISO 9001 certified laboratory in California. Like our other research peptides, it ships as a lyophilized (freeze-dried) powder, which we explain in our lyophilization guide.
The product page does not list a CAS number, molecular formula or molecular weight, so we do not quote them here. Check the vial size and any identifiers on the Kisspeptin-10 product page and on the Certificate of Analysis for your lot.
For unopened vials, follow the storage instructions on the label and product page. The powder stays sealed in its original vial until it is needed in the lab.
How is Kisspeptin-10 tested?
Three checks matter for any peptide: identity by mass spectrometry, purity by HPLC, and content per vial. The Certificate of Analysis (COA) for this product should show each of them. Our line-by-line COA guide covers how to read the report.
A few points are specific to a short peptide like this one:
- Mass match. The measured mass should match the expected mass for the intended sequence. Natural Kisspeptin-10 ends in an amide group rather than a free acid. The two differ by only about one mass unit, so the mass reading should be precise.
- Sequence-related impurities. In a ten-residue chain, a missing or altered amino acid is a large change. HPLC purity helps reveal these closely related by-products.
- Sensitive residues. The sequence contains tryptophan and asparagine, which can degrade through oxidation or deamidation over time. This is one reason to keep an eye on the test date and storage.
How does Kisspeptin-10 fit with our other research peptides?
It is a signaling-pathway tool, not a blend. If you are new to the vocabulary used above, the peptide research glossary defines terms such as agonist and receptor. Kisspeptin-10 is sold for laboratory research use only, not for human or animal use.
Frequently asked questions
Is Kisspeptin-10 the same as Metastin?
It is a piece of it. Metastin is the longer original peptide, and Kisspeptin-10 is its last ten amino acids, labeled Metastin (45-54).
What is GPR54?
GPR54 is the older name for the kisspeptin receptor, now usually written KISS1R. It is a receptor on the surface of cells that Kisspeptin-10 binds to.
What does KP-10 stand for?
KP stands for kisspeptin, and 10 is the number of amino acids in the chain.
Why do researchers use a short fragment instead of the full peptide?
The shorter chain is the minimal sequence that still activates the receptor. That gives a simpler, well-defined molecule for controlled experiments.
Where is our Kisspeptin-10 made?
It is synthesized at a WHO/GMP and ISO 9001 certified laboratory in California. BioPure does not own that facility.
Is Kisspeptin-10 only for research?
Yes. It is labeled for laboratory research use only. Our research use only article explains what that label means.
Every lot we sell has a Certificate of Analysis you can read before you order. Questions before you buy? Our team is in Chandler, Arizona: (888) 745-1505 or our contact page.
View KISSPEPTIN-10All products sold by BioPure Peptides are intended strictly for in-vitro laboratory and research use only. They are not for human or animal consumption. These statements have not been evaluated by the U.S. Food and Drug Administration, and these products are not intended to diagnose, treat, cure, or prevent any disease.